{"id":11154,"date":"2024-01-14T17:56:16","date_gmt":"2024-01-14T17:56:16","guid":{"rendered":"https:\/\/www.herbalreality.com\/?post_type=herb&#038;p=11154"},"modified":"2025-11-08T11:21:25","modified_gmt":"2025-11-08T11:21:25","slug":"horse-chestnut","status":"publish","type":"herb","link":"https:\/\/www.herbalreality.com\/herb\/horse-chestnut\/","title":{"rendered":"Horse chestnut"},"content":{"rendered":"\n<p data-beyondwords-marker=\"2eb6f34b-e624-43a3-9eba-bf9bd5f2e3a3\"><\/p>\n","protected":false},"featured_media":11155,"parent":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"footnotes":"","beyondwords_generate_audio":"1","beyondwords_project_id":"47224","beyondwords_content_id":"2a908291-6b78-4dd0-9b98-cb1621306714","beyondwords_preview_token":"a62f8e85-a35a-4441-ac11-b8aef3f58b24","beyondwords_player_content":"","beyondwords_player_style":"","beyondwords_language_code":"","beyondwords_language_id":"","beyondwords_title_voice_id":"","beyondwords_body_voice_id":"","beyondwords_summary_voice_id":"","beyondwords_error_message":"","beyondwords_disabled":"","beyondwords_delete_content":"","beyondwords_podcast_id":"","beyondwords_hash":"","publish_post_to_speechkit":"","speechkit_hash":"","speechkit_generate_audio":"","speechkit_project_id":"","speechkit_podcast_id":"","speechkit_error_message":"","speechkit_disabled":"","speechkit_access_key":"","speechkit_error":"","speechkit_info":"","speechkit_response":"","speechkit_retries":"","speechkit_status":"","speechkit_updated_at":"","_speechkit_link":"","_speechkit_text":""},"tags":[1929,1662,1663,1661,1928],"conditions":[694,685,696,698],"sustainability":[1575],"sense":[31,17,18,30,1821],"western_action":[1001,992,994,1000,1011],"chinese_action":[],"ayurvedic_action":[],"energetics_action":[1510,1908,1499,1515,1512,1498,1487,1381,1507,1496,1494,1511,1492],"region":[1893],"class_list":["post-11154","herb","type-herb","status-publish","has-post-thumbnail","hentry","tag-anti-oedemic","tag-antioedematous","tag-vasoprotective","tag-vasotonic","tag-venous-tonic","conditions-cardiovascular-system","conditions-digestive-system","conditions-nervous-system","conditions-reproductive-system","sustainability-amber-sustainability-status","sense-astringent-taste","sense-aromatic","sense-bitter","sense-sharp","sense-sour","western_action-bitter","western_action-anti-inflammatory","western_action-antioxidant","western_action-astringent","western_action-febrifuge","energetics_action-acrid","energetics_action-aromatic","energetics_action-astringent","energetics_action-astringent-taste-chinese","energetics_action-bitter-taste-chinese","energetics_action-bitter","energetics_action-dry","energetics_action-neutral","energetics_action-neutral-temperature-chinese","energetics_action-sour","energetics_action-sweet","energetics_action-sweet-taste-chinese","energetics_action-toning","region-western-herbs"],"acf":{"last_reviewed":"20250131","herb_author":1910,"banner_text":"Horse chestnut is a powerful tonic for the venous system","latin_name":"<em>Aesculus hippocastanum<\/em>","pseudonym_name":"","family_name":"Sapindaceae","herb_summary":"Horse chestnut is a vascular tonic used both internally and externally to treat chronic venous insufficiency and varicose veins.","key_benefits":"Venous tonic\r\nAnti-inflammatory\r\nChronic venous insufficiency\r\nVaricose veins","how_does_it_feel":"<span style=\"font-weight: 400;\">Horse chestnut seed tincture smells slightly sweet, aromatic and metallic. It is an interesting aroma, like plastic or chemicals, warning of the possibility of toxicity in high doses. The taste is similar, slightly aromatic and perfumy, bitter, sharp, sour and then acrid in the throat. It foams easily when swished in the mouth, which is quickly replaced by a tightening and tacky sensation from the astringent tannins. It is reminiscent of soap or detergent, reflecting the saponin constituents, which also leave a metallic taste in the throat. The flavonoids contribute to the sour taste, and the bitterness comes from the terpenoid saponins. When taken on an empty stomach, the saponins can cause a mild irritation, which can be eased by consuming some food with the herb.<\/span>\r\n\r\n<em><span style=\"font-weight: 400; color: #ed6e17;\">Please note: Internal use is contraindicated in some cases, refer to <a href=\"https:\/\/www.herbalreality.com\/herb\/horse-chestnut\/#safety\">Safety section<\/a> below.<\/span><\/em>","hdif_image_1":11155,"hdif_image_2":11157,"hdif_image_3":11156,"hdif_video":"https:\/\/youtu.be\/ehR13vOvF1k","sense":[17,31,18,30,1821],"what_can_i_use_it_for":"[caption id=\"attachment_11156\" align=\"alignright\" width=\"554\"]<img class=\" wp-image-11156\" src=\"https:\/\/i.herbalreality.com\/wp-content\/uploads\/2024\/01\/14174811\/Horse-chestnut-conkers-Aesculus-hippocastanum-600x400.jpg\" alt=\"Horse chestnut conkers (Aesculus hippocastanum)\" width=\"554\" height=\"369\" \/> Horse chestnut conkers (<em>Aesculus hippocastanum<\/em>)[\/caption]\r\n\r\n<span style=\"font-weight: 400;\">It is the seed or conker from the horse chestnut tree which is used medicinally. Horse chestnut seed is astringent, anti-inflammatory, a circulatory stimulant, and a tonic for the peripheral vascular system (1,2). It is used internally and externally to strengthen the walls of the small blood vessels, and is most commonly used to treat varicose veins, haemorrhoids and other issues related to venous insufficiency (1).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Horse chestnut is an anti-inflammatory tonic for the vascular system, specific for strengthening the venous and capillary walls. This reduces capillary permeability which decreases oedema, and tones the walls of the blood vessels to move congestion by supporting the return of blood from the periphery. This support for the blood vessel walls enhances elasticity, improves blood flow and venous return, which prevents the pooling of blood responsible for varicose veins and haemorrhoids (3).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Horse chestnut can be useful in conditions where local tissue oedema is causing pain, such as compression neuropathies like carpal tunnel syndrome and spinal disk compression, as well as congestive menstrual pain (4).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The seed can be crushed and made into a tincture or decoction, although internal use requires some caution, and guidance is recommended from a medical herbalist. For external use, a tincture or decoction can be applied directly to the skin as a liniment or compress, or used as an ingredient to make a lotion, balm or gel.\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The saponins in the seed are extracted by soaking the crushed water, which can be used as a soap or detergent substitute to clean clothes, stop mould, and deter clothes moths (1,5,6).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Constituents extracted from horse chestnut seed, particularly aescin, are a common ingredient in cosmetic products, often promoted for skin tightening (7). The tannins will also contribute to this action, and a wash or skin toner can be made from an infusion or a diluted tincture for this purpose. <\/span>","into_the_heart_of":"[caption id=\"attachment_11157\" align=\"alignright\" width=\"578\"]<img class=\" wp-image-11157\" src=\"https:\/\/i.herbalreality.com\/wp-content\/uploads\/2024\/01\/14174819\/Horse-chestnut-flowers-Aesculus-hippocastanum-600x457.jpg\" alt=\"Horse chestnut flowers (Aesculus hippocastanum)\" width=\"578\" height=\"440\" \/> Horse chestnut flowers (<em>Aesculus hippocastanum<\/em>)[\/caption]\r\n\r\n<span style=\"font-weight: 400;\">The pharmacologically active constituents in horse chestnut seed are saponins (collectively referred to as aescin), coumarins and flavonoids (2).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Horse chestnut has anti-exudative and tightening actions on the vasculature via mechanisms of action related to the anti-inflammatory processes of the body.\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Horse chestnut seed extract has an inhibitory effect on catalytic enzymes such as collagenase, hyaluronidase and beta-glucuronidase, which break down capillary walls (8,9). In chronic pathological conditions of the vascular system, this lysosomal enzyme activity is increased, causing a breakdown of the mucopolysaccharides in the capillary and venous walls (10). The saponins in horse chestnut inhibit the activity of these enzymes, which improves the integrity and function of these vessels by decreasing vascular permeability (8,9,10). This reduction in vascular permeability decreases the filtration rate of small proteins, electrolytes and water into the interstitial space <\/span><span style=\"font-weight: 400;\">(<\/span><span style=\"font-weight: 400;\">11). This affects the initial phase of inflammation by exerting a 'sealing' effect on capillaries and by reducing the number and diameter of capillary pores, reducing vascular leakage, oedema, and swelling (2).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The triterpene saponin aescin, tones the veins by increasing the sensitivity of calcium ion channels, and enhancing venous contractile activity, resulting in the venotonic action (12). Additionally, these saponins increase venous tone by increasing prostaglandin synthesis in the vascular tissue, which induces contraction of the venous tissues (2). This vasoconstriction increases the venous tone and raises the flow velocity of blood in the veins (8). The contraction of the veins, combined with the decreased permeability of the capillaries improves the peripheral vascular tone and reduces venous swelling and oedema.<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The flavonoids and tannins are recognised as having anti-inflammatory and astringent properties, respectively (2). The coumarin aesculin is antioxidant, anti-inflammatory and tonic to the venous vessels (13).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Energetically, horse chestnut is cooling, drying and constricting (5,14).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">As a flower essence, horse chestnut is for those who repeat the same mistakes without learning from them (5). It helps people to gain knowledge and wisdom from mistakes, by being more aware and observant of the present moment (15). Failure to learn from mistakes can often be linked to poor boundary setting, and horse chestnut can help enforce healthy personal boundaries (16). It can also be a good remedy for children who are absent minded and need support to be more attentive (15). Matthew Wood considers horse chestnut to be an excellent remedy for obsessive and compulsive thinking, where someone feels they have no control over the thoughts racing around their head (17).\u00a0<\/span>","tradtional_uses":"[caption id=\"attachment_11155\" align=\"alignright\" width=\"570\"]<img class=\" wp-image-11155\" src=\"https:\/\/i.herbalreality.com\/wp-content\/uploads\/2024\/01\/14174746\/Horse-chestnut-Aesculus-hippocastanum-600x400.jpg\" alt=\"Horse chestnut (Aesculus hippocastanum)\" width=\"570\" height=\"380\" \/> Horse chestnut (<em>Aesculus hippocastanum<\/em>)[\/caption]\r\n\r\n<span style=\"font-weight: 400;\">Horse chestnut has a long history of use for treating many ailments including peripheral vascular issues, haemorrhoids, rheumatism, leg cramps, neuralgia, bladder issues, gastrointestinal disorders, diarrhoea and fever (1,2). It was regarded as a remedy for congestion and engorgement, to ease the associated throbbing sensations and dull aches in any part of the body (4).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">In 1898, horse chestnut seed and bark were listed in <\/span><i><span style=\"font-weight: 400;\">King's American Dispensatory<\/span><\/i><span style=\"font-weight: 400;\"> as a tonic, astringent, febrifuge, narcotic, and antiseptic (18). The bark was made into a tea and used for its tonic, astringent, febrifuge, narcotic and antiseptic properties, to treat malaria, fever and dysentery (1,19). Externally, a strong infusion of the bark was applied to \u201cgangrenous and ill-conditioned ulcers\u201d, and an oil made from the powdered seed locally applied to \u201dneuralgic\u201d and \u201drheumatic affections\u201d (18). <\/span>\r\n\r\n<span style=\"font-weight: 400;\">In the 1800s, the primary internal use was for neuralgia of the internal viscera, due to vascular congestion, engorgement and stasis, with a sense of soreness, throbbing, and malaise all over the body (18). Horse chestnut was known to exert a specific influence on rectal disorders, such as rectal irritation, haemorrhoids, rectal neuralgia and proctitis, by relieving itching, heat, pain, aching, and spasms (18). The dose of the seed tincture was 5\u201320 drops (\u00bc\u20131 ml) (19).<\/span>","what_practioners_say":"[caption id=\"attachment_60863\" align=\"alignright\" width=\"574\"]<img class=\" wp-image-60863\" src=\"https:\/\/i.herbalreality.com\/wp-content\/uploads\/2024\/01\/31114050\/Horse-chestnut-conkers-Aesculus-hippocastanum-1-1000x654.jpg\" alt=\"Horse chestnut (Aesculus hippocastanum)\" width=\"574\" height=\"375\" \/> Horse chestnut (<em>Aesculus hippocastanum<\/em>)[\/caption]\r\n<h3>Circulatory system<\/h3>\r\n<span style=\"font-weight: 400;\">Horse chestnut is most commonly used to treat conditions arising from venous congestion, such as varicose veins and haemorrhoids (1). The Commission E, which provides therapeutic guides for herbal medicine professionals, approves use for treatment of symptoms of chronic venous insufficiency (CVI), including varicose veins, oedema, pain, feelings of heaviness in the legs, night cramps, itching and swelling (11,20). Herbal medicine practitioners will usually prescribe herbs as combination, bespoke medicines, however horse chestnut seed extract is licensed by the European Medicines Agency for use internally and externally in commercially available herbal medicine products (21). It is approved to treat CVI (characterised by swollen legs, varicose veins, a feeling of heaviness in the legs, pain, tiredness, itching, tension and cramps in the calves), as well as bruises, local swelling and haematoma (21).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Horse chestnut has anti-exudative and tightening actions on the vasculature, which restores functionality of the vein wall, and reduces the oedema and venous swelling associated with these conditions. The actions on the vessels in the circulatory system make horse chestnut uniquely suited to both the internal and external treatment of phlebitis (vein inflammation), varicosities, and haemorrhoids (10). In these chronic pathological vascular conditions, there is increased activity of enzymes which cause a breakdown of the capillary walls (10). The saponins in horse chestnut inhibit these enzymes, decreasing vascular permeability which leads to exudation and oedema and the symptoms of CVI (10,22). The combination of the vascular tonic effect and the improved capillary resilience has been demonstrated in clinical trials to improve symptoms in patients with venous insufficiency (8,23).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The active constituents are absorbed trans-dermally and orally, although the bioavailability of the saponins across the gastrointestinal tract (GIT) is low (4). For this reason, horse chestnut is often concurrently included in both oral and topical formulas. However, in some individuals, internal use may be contraindicated, and topical use is to be discontinued if the skin is broken, due to the haemolytic effect of the saponins.\u00a0\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Internally, horse chestnut combines well with:<\/span>\r\n<ul>\r\n \t<li><a href=\"https:\/\/www.herbalreality.com\/herb\/yarrow\/\"><span style=\"font-weight: 400;\">Yarrow<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Achillea millefolium<\/span><\/i><span style=\"font-weight: 400;\">) to stimulate the peripheral circulation<\/span><\/li>\r\n \t<li><a href=\"https:\/\/www.herbalreality.com\/herb\/gotu-kola\/\"><span style=\"font-weight: 400;\">Gotu kola<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Centella asiatica<\/span><\/i><span style=\"font-weight: 400;\">) to support the connective tissues<\/span><\/li>\r\n \t<li><a href=\"https:\/\/www.herbalreality.com\/herb\/bilberry\/\"><span style=\"font-weight: 400;\">Bilberry<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Vaccinium myrtillus<\/span><\/i><span style=\"font-weight: 400;\">) to further support the integrity of the microvasculature<\/span><\/li>\r\n \t<li><a href=\"https:\/\/www.herbalreality.com\/herb\/prickly-ash\/\"><span style=\"font-weight: 400;\">Prickly ash<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Zanthoxylum americanum<\/span><\/i><span style=\"font-weight: 400;\">) as an analgesic which also stimulates the peripheral circulation<\/span><\/li>\r\n<\/ul>\r\n<h3>Topical application<\/h3>\r\n<span style=\"font-weight: 400;\">In cases where horse chestnut may be contraindicated, for example in cases of gastric ulcers or gastrointestinal irritability, external applications are preferable. The additional benefit of an external application is the opportunity to massage the area of swelling and oedema. Rubbing a cream, balm or gel into the skin, massaging towards the centre of the body, provides an additional support to the circulatory flow back to the heart, as well as dissipating the oedema from the surrounding tissues. Other lifestyle advice to support CVI and varicose veins includes the use of compression stockings, avoiding standing for long periods, frequently walking around to support blood flow, and sleeping with the legs on a pillow or elevating the foot of the bed slightly.<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Because horse chestnut is so effective at supporting the peripheral blood vessels it also makes an effective external application for spider veins, capillary fragility, and those who bruise easily(6,24). Other topical applications include haematomas, contusions, sprains and rheumatic pains (5,24).\u00a0\u00a0<\/span>\r\n<h3>Deep vein thrombosis (DVT)<\/h3>\r\n<span style=\"font-weight: 400;\">CVI, phlebitis (inflammation of veins) and varicose veins carry an increased risk of DVT, with horse chestnut treatment reducing this risk (24, 25,26). Horse chestnut can be recommended for use internally or externally before and during long flights to reduce oedema and for preventing thrombosis (7). Horse chestnut can be used prophylactically before surgical treatment, in those at risk of DVT (22).<\/span>\r\n<h3>Neurological<span style=\"font-weight: 400;\">\u00a0<\/span><\/h3>\r\n<span style=\"font-weight: 400;\">Horse chestnut may be indicated in disorders where local tissue oedema may be causing nerve compression, such as trigeminal neuralgia, Bell\u2019s palsy, <\/span><a href=\"https:\/\/www.herbalreality.com\/condition\/sciatica\/\"><span style=\"font-weight: 400;\">sciatica<\/span><\/a><span style=\"font-weight: 400;\">, disc lesions and hernia, carpal tunnel syndrome (24). Similarly, horse chestnut supports microcirculation in the skin in cases of diabetic neuropathy and diabetic ulcerated lesions (22).<\/span>\r\n<h3>Digestive system<\/h3>\r\n<span style=\"font-weight: 400;\">The astringent tannins (anthocyanidins) are helpful in relieving diarrhoea, but can be constipating for those who are prone (3, 16).<\/span>\r\n<h3>Reproductive system<span style=\"font-weight: 400;\">\u00a0<\/span><\/h3>\r\n<span style=\"font-weight: 400;\">In women, horse chestnut can be used to address any blood stasis and venous congestion in the pelvic region which could be causing menstrual pain and dysfunction (26). It can also help to reduce oedema associated with premenstrual fluid retention (26). Horse chestnut can also be used prophylactically or in the treatment of venous problems associated with the use of the contraceptive pill (22).\u00a0<\/span>","research":"[caption id=\"attachment_60862\" align=\"alignright\" width=\"576\"]<img class=\" wp-image-60862\" src=\"https:\/\/i.herbalreality.com\/wp-content\/uploads\/2024\/01\/31114049\/Horse-chestnut-leaves-Aesculus-hippocastanum-1000x786.jpg\" alt=\"Horse chestnut (Aesculus hippocastanum)\" width=\"576\" height=\"452\" \/> Horse chestnut (<em>Aesculus hippocastanum<\/em>)[\/caption]\r\n\r\n<span style=\"font-weight: 400;\">Clinical data supports both internal and external use of horse chestnut seed extract for symptoms of chronic venous insufficiency (CVI), such as varicose veins and haemorrhoids.<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Many studies have assessed the effects of horse chestnut seed extract in patients with CVI, a common condition which causes oedema of the lower leg (2).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">A review of five clinical trials demonstrated the effectiveness of horse chestnut seed extract (20\u201350 mg aescin) used either internally or externally, in patients with chronic venous insufficiency (CVI) and varicose veins (8). The preparations were effective at reducing lower leg oedema (swelling), and improving leg pain, heaviness, and itching (8).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">A Cochrane review of randomised controlled trials (RCT) reviewed the efficacy and safety of horse chestnut seed extract in treating CVI, compared to either a placebo or compression treatment (23). A total of seventeen RCTs were included in the analysis, using internal doses of standardised extracts equivalent to 100\u2013150 mg aescin daily. The study showed a superior improvement of horse chestnut over placebo, with equivalent efficacy for compression stockings (23). It was concluded that horse chestnut seed can increase venous tone and improve venous return leading to reduced swelling, pain and itching (23).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Mechanistically, a significant reduction of transcapillary filtration has been demonstrated in pharmacological studies involving human subjects, and in various randomised double-blind and cross-over studies (11). These studies demonstrate a significant improvement in the symptoms of CVI, including sensations of tiredness, heaviness and tension, pruritus, pain and leg swelling (11).<\/span>","did_you_know":"<span style=\"font-weight: 400;\">The seeds were traditionally used to treat respiratory problems in horses, which is the root of the common name (5,27). The name of the seed or \u201cconker\u201d comes from a game played with snails, called \u2018conqueror\u2019 or \u2018conche\u2019 (27). <\/span>","additional_information_right":{"illustration":31651},"additional_information_left":{"botany":"<span style=\"font-weight: 400;\">Horse chestnut is a monoecious, broad-leaved, deciduous tree, which grows rapidly to around 35 m tall and 15 m wide (1,30). The trees have a dome shaped crown with side branches which sweep down and turn up at the ends (27). The leaves are palmately compound, divided into five or seven oval, pointed, leaflets on a long petiole (1,27,28). The leaflets are irregularly double toothed and prominently veined, with the middle leaflet the largest, measuring approximately 25 cm long (27).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Spectacular flower heads develop in May in long (30 cm), erect branched clusters (panicles) of around 100 white\/yellow\/pink flowers, with five flowers per branch (27). The panicles look like candles all over the tree, and give it one of its common names, candelabra tree (28).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The green, spiky fruits ripen in autumn and split into 2\u20133 segments to reveal 1\u20133 brown, shiny seeds (conkers), with a dull, pale brown \u2018scar\u2019 where it was attached to the inside of the seed shell (19,27).<\/span>","common_names":"<ul>\r\n \t<li><span style=\"font-weight: 400;\">Buck eye<\/span><\/li>\r\n \t<li><span style=\"font-weight: 400;\">Conker tree<\/span><\/li>\r\n \t<li><span style=\"font-weight: 400;\">Spanish chestnut<\/span><\/li>\r\n \t<li><span style=\"font-weight: 400;\">Candelabra tree<\/span><\/li>\r\n<\/ul>","safety":"<span style=\"font-weight: 400;\">Horse chestnut is not suitable for use by children (29).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Avoid in pregnancy due to insufficient safety data, and only consume when breast-feeding under the guidance of a medical practitioner (1,29). Horse chestnut seed extract is regarded as safe to take for adults within the recommended dosages for a short duration of time (1). <\/span>","interactions":"<span style=\"font-weight: 400;\">Do not take internally in conjunction with blood thinning medications including aspirin and warfarin, due to the coumarin content which may have anticoagulant effects (1,29).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Horse chestnut seed extracts have hypoglycaemic activity and potentially an additive effect, if taken with hypoglycaemic drugs such a metformin (29). <\/span>","contraindications":"<span style=\"font-weight: 400;\">Horse chestnut preparations should be avoided or only taken under the guidance of a medical herbalist if there are any kidney ailments, due to potential toxicity to the renal system (1,2).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Avoid in cases of liver dysfunction due to potential toxicity (29).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The saponins can be an irritant to the stomach and gastrointestinal tract (2). Internal consumption should be avoided on an empty stomach and in those with stomach or gastrointestinal tract ailments including gastro-oesophageal reflux and digestive ulcers (24, 29).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Topical applications should not be applied to broken or ulcerated skin, around the eyes or on the mucous membranes, due to the irritant effect of the saponins (21,24,29).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The Committee on Herbal Medicinal Products (21) states that if there is inflammation of the skin, thrombophlebitis or subcutaneous induration (hardened, raised area under the skin), severe pain, ulcers, sudden swelling of one or both legs, cardiac or renal insufficiency, a medical professional should be consulted before use of horse chestnut products (21).<\/span>","preparation":"<ul>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tincture<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Infusion<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Standardised extract<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lotion<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Balm<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bath<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Wash<\/span><\/li>\r\n<\/ul>\r\n<span style=\"font-weight: 400;\">Horse chestnut seed extract is licensed for use internally and externally in commercially available herbal medicine products (21).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Tinctures, infusions and oils made from the whole seed will contain a greater range of constituents and provide additional benefits beyond those purely made of the isolated aescin extracts. Although standardised extracts of horse chestnut seed are commercially available, the total anti-inflammatory activity is greater for a whole horse-chestnut extract compared to isolated aescin extracts (2). <\/span>","dosage":"<ul>\r\n \t<li><b>Infusion<\/b><span style=\"font-weight: 400;\">: 1\u20132 teaspoons (1\u20135 g) dried seed, infused 10\u201315 minutes, three times per day (10)<\/span><\/li>\r\n \t<li><b>Tincture: (1:5<\/b><span> |<\/span><b> 40%)<\/b><span>: 0.5\u20133 ml per day, in divided doses of 0.2\u20131 ml, three times per day, <\/span><span>(1,2,10).<\/span><span> Up to 15\u201335ml (14,24)<\/span><\/li>\r\n \t<li><b>Fluid extract (1:1)<\/b><span>: 0.5\u20131.2 ml per day (22)<\/span><\/li>\r\n \t<li><b>Commercial extracts<\/b><span>: 21\u201350 mg aescin, 2\u20133 times per day (10,21). Typical extract is standardised to 16\u201320% aescin, requiring 300\u2013900 mg\/ml of the extract per day (10,<\/span><span>20<\/span><span>). Commission E recommends 100 mg aescin per day in the form of commercially available extracts (<\/span><span>20). <\/span><\/li>\r\n \t<li><b>Tablets\/<\/b><span>c<\/span><b>apsules<\/b><span>: 200 mg of 5:1 extract, containing 405\u201350 mg aescin, 2\u20133 times per day (4)<\/span><\/li>\r\n<\/ul>\r\n<h3>Topical<\/h3>\r\n<ul>\r\n \t<li><b>Cream\/lotion<\/b><span style=\"font-weight: 400;\">: Made from tincture and\/or decoction (see <a href=\"https:\/\/www.herbalreality.com\/herb\/horse-chestnut\/#recipe\">recipe<\/a>). Commercial preparations containing 2% aescin, applied at dose 50\u201375 mg aescin every 12 hours <\/span><span style=\"font-weight: 400;\">(1)<\/span><\/li>\r\n \t<li><b>Wash\/bath<\/b><span>: 50 g seed in 500 ml boiling water, applied three times per day (1)<\/span><\/li>\r\n \t<li><b>Oil<\/b><span>: Dried seed (1:4), applied 1\u20132 times per day (14)<\/span><\/li>\r\n<\/ul>","constituents":"<ul>\r\n \t<li><b>Saponins (terpenoid)<\/b><span style=\"font-weight: 400;\">: A complex mixture of over 30 saponins, collectively referred to as 'aescin' (3\u201310%); <\/span><span style=\"font-weight: 400;\">\u03b1<\/span><span style=\"font-weight: 400;\">- and <\/span><span style=\"font-weight: 400;\">\u03b2<\/span><span style=\"font-weight: 400;\">-aescin (2,7,13)<\/span><\/li>\r\n \t<li><b>Coumarins<\/b><span>: Aesculin (aesculetin glycoside), fraxin (fraxetin glucoside), scopoline, (scopoletin glucoside) (2,13)<\/span><\/li>\r\n \t<li><b>Flavonoids<\/b><span>: Flavonol (kaempferol, quercetin) glycosides including astragalin, isoquercetrin, rutin; leucocyanidin (quercetin derivative); anthocyanidins (2,7)<\/span><\/li>\r\n \t<li><b>Tannins<\/b><span>: Condensed type, epicatechin (2)<\/span><\/li>\r\n \t<li><b>Other<\/b><span>: Allantoin, amino acids (adenine, adenosine, guanine), choline, citric acid, fatty acids (linolenic, palmitic, steric), phytosterols (1,2)<\/span><\/li>\r\n<\/ul>","plant_part_used":"<ul>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seed (conker)\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bark<\/span><\/li>\r\n<\/ul>"},"habitat":"<span style=\"font-weight: 400;\">Horse chestnut is native to Albania, Bulgaria, Greece, Turkey, Turkmenistan, Yugoslavia, Western Asia, and has been introduced widely across Europe and North America (1,31). The species is found in deciduous forests, woodlands, rocky slopes, valleys and canyons (30,32). It was introduced into the UK in 1629 and is found in deciduous and mixed woodland, and is widely planted in parkland, large gardens and estates, churchyards, urban streets and village greens (32). Horse chestnut trees occasionally self-seed in scrubby areas, waste ground or rough grassland, and woodland, but are cultivated and naturalised in most temperate regions (7,32).<\/span>","sustainability":"<span style=\"font-weight: 400;\"><img class=\" wp-image-10963 alignright\" src=\"https:\/\/i.herbalreality.com\/wp-content\/uploads\/2023\/12\/11190002\/sustainability-icon-amber-new.jpg\" alt=\"\" width=\"344\" height=\"343\" \/>There is no legislation on the trade of the species from the Convention on International Trade in Endangered Species of Wild Fauna and Flora (33).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The International Union for Conservation of Nature (IUCN) global assessed <\/span><i><span style=\"font-weight: 400;\">Aesculus hippocastanum\u00a0<\/span><\/i><span style=\"font-weight: 400;\">in 2017 and it is listed as Vulnerable (30). They state that the species is widely distributed in many parts of Europe, but populations\u00a0are declining and have been significantly damaged by the leaf-miner moth\u00a0<\/span><i><span style=\"font-weight: 400;\">Cameraria ohridella<\/span><\/i><span style=\"font-weight: 400;\">\u00a0(30). The moth impairs the growth and survival of trees by reducing seed weight, germination rates and seedling growth, which may endanger the long term persistence of the species (30). The species is threatened across most of the native range, it is endangered in Bulgaria, and critically endangered in Albania (30). According to extinction risk predictions, horse chestnut is not currently at risk of extinction (31). Collection of seed for use as herbal medicine and by the pharmaceutical industry presents a threat in Greece, whilst in Bulgaria, seed is primarily collected from cultivated sources (30). Horse chestnut is widely cultivated in Europe, Russia and North America, with cultivated sources being recommended to protect nature habitats <\/span><span style=\"font-weight: 400;\">(1).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Horse chestnut has no status ranking by Nature Serve, where the distribution across North America has not been assessed (34). It does not appear on the U.S. or Canadian Endangered Species acts, or on the United Plant Savers list of species at risk (34,35).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">In the UK, its distribution is stable, with an increase in areas of Ireland and Northern Scotland due to the planting of trees (32). Horse chestnut is not listed by The Vascular Plant, Red Data List, For Great Britain, and does not appear on the UK Biodiversity Action Plan List of Priority Habitats and Species (<\/span><span style=\"font-weight: 400;\">37).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Habitat loss and over-harvesting from the wild are two of the biggest threats faced by medicinal plant species. There are an increasing number of well-known herbal medicines at risk of extinction. We must, therefore, ensure that we source our medicines with sustainability in mind.<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The herb supplement industry is growing at a rapid rate and until recent years a vast majority of medicinal plant produce in global trade was of unknown origin. There are some very real and urgent issues surrounding sustainability in the herb industry. These include environmental factors that affect the medicinal viability of herbs, the safety of the habitats that they are taken from, as well as the welfare of workers in the trade.<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The botanical supply chain efforts for improved visibility (transparency and traceability) into verifiably sustainable production sites around the world is now certificated through the emergence of credible international voluntary sustainability standards (VSS).<\/span><span style=\"font-weight: 400;\">\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Read our article on <\/span><a href=\"https:\/\/www.herbalreality.com\/herbalism\/safety\/herbal-quality-safety-what-know-before-you-buy\/\"><span style=\"font-weight: 400;\">Herbal quality &amp; safety: What to know before you buy<\/span><\/a><span style=\"font-weight: 400;\">\u00a0and <\/span><a href=\"https:\/\/www.herbalreality.com\/herbalism\/western-herbal-medicine\/where-your-herbs-come-from\/\"><span style=\"font-weight: 400;\">Sustainable sourcing of herbs<\/span><\/a><span style=\"font-weight: 400;\"> to learn more about what to look for and questions to ask suppliers about sustainability.<\/span>","sustainability_content":"","sustainability_alternatives":"","quality_control":"<span style=\"font-weight: 400;\">Herbal medicines are often very safe to take; however, their safety and efficacy can be jeopardised by quality issues. So, it is important to buy herbal medicines from a reputable supplier, from sources known to test their herbs to ensure there is no contamination, adulteration or substitution with incorrect plant matter, as well as ensuring that recognised marker compounds are at appropriate levels in the herbs.<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Some important quality assurances to look for are certified organic labelling, the correct scientific\/botanical name, and the availability of information from the supplier about ingredient origins. A supplier should be able to tell you where the herbs have come from, what contaminants are not in the herb, and what the primary compounds are.<\/span>","how_to_grow":"<span style=\"font-weight: 400;\">The fresh seeds can be planted outdoors in autumn, with the scar pointing down into the soil (1). Soaking for 24 hours can aid gemination (1,19). Horse chestnut trees grow rapidly and will tolerate poor soil and varying light conditions, though they will not bear seeds until 20 years of age (1). <\/span>","recipe":"[caption id=\"attachment_60864\" align=\"alignright\" width=\"566\"]<img class=\" wp-image-60864\" src=\"https:\/\/i.herbalreality.com\/wp-content\/uploads\/2024\/01\/31114304\/Horse-chestnut-Aesculus-hippocastanum-1-1000x666.jpg\" alt=\"Horse chestnut (Aesculus hippocastanum)\" width=\"566\" height=\"377\" \/> Horse chestnut (<em>Aesculus hippocastanum<\/em>)[\/caption]\r\n<h3>Vein-soothing lotion*<\/h3>\r\n<h4>Ingredients<\/h4>\r\n<ul>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">250 g <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/aloe-vera\/\"><span style=\"font-weight: 400;\">aloe vera<\/span><\/a><span style=\"font-weight: 400;\"> gel or plain base cream<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">10 ml horse chestnut leaf infused oil<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">10 ml <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/calendula\/\"><span style=\"font-weight: 400;\">calendula<\/span><\/a><span style=\"font-weight: 400;\"> oil<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">10 ml horse chestnut seed tincture<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">10 ml <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/yarrow\/\"><span style=\"font-weight: 400;\">yarrow<\/span><\/a><span style=\"font-weight: 400;\"> tincture<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">10 ml <\/span><a href=\"https:\/\/i.herbalreality.com\/wp-content\/uploads\/2023\/10\/31093713\/Conditions-full-body-illustration.png\"><span style=\"font-weight: 400;\">witch hazel<\/span><\/a><span style=\"font-weight: 400;\"> tincture<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">10 ml witch hazel distilled water<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">20 ml <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/mint\/\"><span style=\"font-weight: 400;\">peppermint<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/rosemary\/\"><span style=\"font-weight: 400;\">rosemary<\/span><\/a><span style=\"font-weight: 400;\"> essential oil<\/span><\/li>\r\n<\/ul>\r\n<h4>Instructions<\/h4>\r\n<ul>\r\n \t<li><span style=\"font-weight: 400;\">Place the aloe vera or base cream in a bowl and gradually whisk in the oils, one teaspoon at a time. Use the same method to gradually add the tincture, whisking thoroughly, before adding the essential oil and then finally, the witch hazel water.\u00a0<\/span><\/li>\r\n \t<li><span style=\"font-weight: 400;\">Apply twice per day to varicose veins, thread veins or haemorrhoids.<\/span><\/li>\r\n<\/ul>\r\n* Adapted from Chown and Walker (28)","references":"<ol>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stobart, A. <\/span><i><span style=\"font-weight: 400;\">The Medicinal Forest Garden Handbook: growing, harvesting and using healing trees and shrubs in a temperate climate<\/span><\/i><span style=\"font-weight: 400;\">. Permanent Publishers; 2020.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Barnes, J., Anderson, L.A. and Phillipson, J.D. <\/span><i><span style=\"font-weight: 400;\">Herbal medicines: a guide for healthcare professionals:<\/span><\/i><span style=\"font-weight: 400;\"> Third Edition. Pharmaceutical press; 2007.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">McIntyre, A.\u00a0<\/span><i><span style=\"font-weight: 400;\">The Complete Herbal Tutor: The Definitive Guide to the Principles and Practices of Herbal Medicine<\/span><\/i><span style=\"font-weight: 400;\">. Aeon Books, 2019.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bone K and Mills S.\u00a0<\/span><i><span style=\"font-weight: 400;\">Principles and Practice of Phytotherapy: Modern Herbal Medicine<\/span><\/i><span style=\"font-weight: 400;\">. Elsevier Health Sciences; 2013.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mars, B. <\/span><i><span style=\"font-weight: 400;\">The Desktop Guide to Herbal Medicine.<\/span><\/i><span style=\"font-weight: 400;\"> Basic Health Publications Inc; 2007.<\/span><\/li>\r\n \t<li aria-level=\"1\"><span style=\"font-weight: 400;\">Burton-Seal, J. and Seal, M. <\/span><i><span style=\"font-weight: 400;\">Hedgerow Medicine: harvest and make your own herbal remedies<\/span><\/i><span style=\"font-weight: 400;\">. Merlin Unwin Books; 2014.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heinrich, M., Barnes, J., Prieto-Garcia, J., Gibbons, S. and Williamson, E.M.\u00a0<\/span><i><span style=\"font-weight: 400;\">Fundamentals of Pharmacognosy and Phytotherapy<\/span><\/i><span style=\"font-weight: 400;\">. Third Edition. Elsevier Health Sciences; 2018.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Suter A, Bommer S, Rechner J. Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: a review of 5 clinical studies. <\/span><i><span style=\"font-weight: 400;\">Advances in therapy<\/span><\/i><span style=\"font-weight: 400;\">. 2006 Jan;23:179-90. <\/span><a href=\"https:\/\/doi.org\/10.1007\/BF02850359\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1007\/BF02850359<\/span><\/a><span style=\"font-weight: 400;\">\u00a0\u00a0\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Murray, MT. <\/span><i><span style=\"font-weight: 400;\">The Encyclopaedia of Natural Medicine (Third Edition)<\/span><\/i><span style=\"font-weight: 400;\">. Atria Paperback; 2012.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hoffmann D.\u00a0<\/span><i><span style=\"font-weight: 400;\">Medicinal Herbalism, The Science and Practice of Herbal Medicine<\/span><\/i><span style=\"font-weight: 400;\">. Healing Arts Press; 2003.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blumenthal M, Busse WR. Horse Chestnut Seed. In: <\/span><i><span style=\"font-weight: 400;\">The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines<\/span><\/i><span style=\"font-weight: 400;\">. American Botanical Council; 1999. Accessed January 13, 2025. <\/span><a href=\"https:\/\/www.herbalgram.org\/resources\/commission-e-monographs\/monograph-approved-herbs\/horse-chestnut-seed\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/www.herbalgram.org\/resources\/commission-e-monographs\/monograph-approved-herbs\/horse-chestnut-seed<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sirtori CR. Aescin: pharmacology, pharmacokinetics and therapeutic profile.\u00a0<\/span><i><span style=\"font-weight: 400;\">Pharmacological Research. <\/span><\/i><span style=\"font-weight: 400;\">2001;44(3), 183-193. <\/span><a href=\"https:\/\/doi.org\/10.1006\/phrs.2001.0847\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1006\/phrs.2001.0847<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ganora, L. Herbal Constituents: <\/span><i><span style=\"font-weight: 400;\">Foundations of Phytochemistry<\/span><\/i><span style=\"font-weight: 400;\">. Herbalchem Press; 2009.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Easley T, Horne S. <\/span><i><span style=\"font-weight: 400;\">The Modern Herbal Dispensatory: A Medicine-Making Guide<\/span><\/i><span style=\"font-weight: 400;\">. North Atlantic Books; 2016.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">McIntyre A. Flower Power: flower remedies for healing body and soul through herbalism, homoeopathy, aromatherapy, and flower essences. Henry Holt; 1996.\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Jones, L. A <\/span><i><span style=\"font-weight: 400;\">Working Herbal Dispensary: respecting herbs as individuals<\/span><\/i><span style=\"font-weight: 400;\">. Aeon; 2023.\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Wood M.\u00a0<\/span><i><span style=\"font-weight: 400;\">The Earthwise Herbal Volume 1: A Complete Guide to New World Medicinal Plants<\/span><\/i><span style=\"font-weight: 400;\">. North Atlantic Books; 2008.\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Felter H. W, Lloyd J. U. Kings American Dispensary; 18th Edit; 1898. Reprinted on Henritttas Herbpages. Accessed January 8, 2025. <\/span><a href=\"https:\/\/www.henriettes-herb.com\/eclectic\/kings\/aesculus-hipp.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/www.henriettes-herb.com\/eclectic\/kings\/aesculus-hipp.html<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Grieve M, Leyel CF, Marshall M. <\/span><i><span style=\"font-weight: 400;\">A Modern Herbal. the Medicinal, Culinary, Cosmetic and Economic Properties, Cultivation and Folk-Lore of Herbs, Grasses, Fungi, Shrubs &amp; Trees with All Their Modern Scientific Uses<\/span><\/i><span style=\"font-weight: 400;\">. Dover Publications; 1982.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blumenthal M, Busse WR. Horse Chestnut Seed Extract.<\/span><i><span style=\"font-weight: 400;\"> Expanded Commission E Monographs: Therapeutic Guide to Herbal Medicines<\/span><\/i><span style=\"font-weight: 400;\">. American Botanical Council; 1999. Accessed January 13, 2025. <\/span><a href=\"https:\/\/www.herbalgram.org\/resources\/expanded-commission-e-monographs\/horse-chestnut-seed-extract\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/www.herbalgram.org\/resources\/expanded-commission-e-monographs\/horse-chestnut-seed-extract\/<\/span><\/a><span style=\"font-weight: 400;\">\u00a0\u00a0\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">European Committee on Herbal Medicine Products (HMPC). <\/span><i><span style=\"font-weight: 400;\">Hippocastani semen -\u00a0herbal medicinal product<\/span><\/i><span style=\"font-weight: 400;\">: European Medicines Agency. Accessed: 11 January, 2025. <\/span><a href=\"https:\/\/www.ema.europa.eu\/en\/medicines\/herbal\/hippocastani-semen\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/www.ema.europa.eu\/en\/medicines\/herbal\/hippocastani-semen<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fisher C. <\/span><i><span style=\"font-weight: 400;\">Materia Medica of Western Herbs<\/span><\/i><span style=\"font-weight: 400;\">. Aeon Books; 2018.\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. <\/span><i><span style=\"font-weight: 400;\">Cochrane database of systematic reviews<\/span><\/i><span style=\"font-weight: 400;\">. 2012(11). <\/span><a href=\"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD003230.pub4\/full\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD003230.pub4\/full<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bone K.\u00a0The Ultimate Herbal Compendium: a desktop guide for herbal therapists. Phytotherapy Press; 2007.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Wilkinson, I., Wilkinson, I. B., Raine, T., Wiles, K., Goodhart, A., Hall, C., &amp; O'Neill, H. Oxford handbook of clinical medicine. Oxford university press; 2017.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reilly, M. <\/span><i><span style=\"font-weight: 400;\">Herbal Medicine and Reproductive Health<\/span><\/i><span style=\"font-weight: 400;\">. Aeon; 2021.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Harding P and Tomblin G. How to Identify Trees. Collins; 1996.\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chown V and Walker K. <\/span><i><span style=\"font-weight: 400;\">The Handmade Apothecary: Healing Herbal Remedies<\/span><\/i><span style=\"font-weight: 400;\">. Kyle Books; 2017.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Brinker, FJ.\u00a0<\/span><i><span style=\"font-weight: 400;\">Herbal Contraindications &amp; Drug Interactions: Plus Herbal Adjuncts with Medicines<\/span><\/i><span style=\"font-weight: 400;\">. Eclectic Medical Publications, 2010.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Allen, DJ. &amp; Khela, S. IUCN red list of threatened species 2017: <\/span><i><span style=\"font-weight: 400;\">Aesculus hippocastanum<\/span><\/i><span style=\"font-weight: 400;\">. IUCN. July 20, 2017. Accessed January 7, 2025. <\/span><a href=\"https:\/\/www.iucnredlist.org\/species\/202914\/122961065\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/www.iucnredlist.org\/species\/202914\/122961065<\/span><\/a><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Royal Botanical Gardens Kew (RBGK). <\/span><i><span style=\"font-weight: 400;\">Aesculus hippocastanum\u00a0L.<\/span><\/i><span style=\"font-weight: 400;\"> Plants of the Word Online (POWO). Accessed January 7, 2025. <\/span><a href=\"https:\/\/powo.science.kew.org\/taxon\/urn:lsid:ipni.org:names:781594-1\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/powo.science.kew.org\/taxon\/urn:lsid:ipni.org:names:781594-1<\/span><\/a><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Wilmore GTD., Aspey N., Stroh TA., Humphrey RJ., Burkmar OL., Pescott DB., &amp; Walker KJ. Horse-chestnut <\/span><i><span style=\"font-weight: 400;\">Aesculus hippocastanum <\/span><\/i><span style=\"font-weight: 400;\">L. BSBI Online Plant Atlas. Published 2020. Accessed January 7, 2025.\u00a0 <\/span><a href=\"https:\/\/plantatlas2020.org\/atlas\/2cd4p9h.cpk\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/plantatlas2020.org\/atlas\/2cd4p9h.cpk<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES). Accessed January 7, 2025. <\/span><a href=\"https:\/\/checklist.cites.org\/#\/en\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/checklist.cites.org\/#\/en<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">NatureServe explorer 2.0. Natureserve.org. Accessed January 7, 2025. <\/span><a href=\"https:\/\/explorer.natureserve.org\/Taxon\/ELEMENT_GLOBAL.2.149458\/Aesculus_hippocastanum\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/explorer.natureserve.org\/Taxon\/ELEMENT_GLOBAL.2.149458\/Aesculus_hippocastanum<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">UPS list of herbs &amp; analogs. United Plant Savers. Published May 14, 2021. Accessed January 7, 2025. <\/span><a href=\"https:\/\/unitedplantsavers.org\/ups-list-of-herbs-analogs\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/unitedplantsavers.org\/ups-list-of-herbs-analogs\/<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cheffings C, Farrell L, (eds), Dines, T.D., Jones, R.A., Leach, S.J., McKean, D.R., Pearman, D.A., Preston, C.D., Rumsey, F.J., Taylor, I. The Vascular Plant Red Data List for Great Britain. Species Status No. 7. Joint National Conservation Committee. 2005. Accessed January 7, 2025. <\/span><a href=\"https:\/\/hub.jncc.gov.uk\/assets\/cc1e96f8-b105-4dd0-bd87-4a4f60449907\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/hub.jncc.gov.uk\/assets\/cc1e96f8-b105-4dd0-bd87-4a4f60449907<\/span><\/a><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">UK Biodiversity Action Plan List of Priority Habitats and Species (2010) <\/span><a href=\"https:\/\/data.jncc.gov.uk\/data\/bdd8ad64-c247-4b69-ab33-19c2e0d63736\/UKBAP-UKListPriorityHabitatsSpecies-V1.4-2010.xls\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/data.jncc.gov.uk\/data\/bdd8ad64-c247-4b69-ab33-19c2e0d63736\/UKBAP-UKListPriorityHabitatsSpecies-V1.4-2010.xls<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\r\n<\/ol>","related_condition":[13213,5953],"related_herb":[1852,1848],"related_article":[4848,5867],"herb_overview_content_one":"","herb_overview_content_two":"","herb_overview_content_three":"","herb_overview_content_four":"","herb_overview_content_five":"","herb_overview_content_six":"","herb_overview_content_seven":"","herb_overview_content_eight":"","botany":"","botanical_description":"","botanical_image":"","common_names":"","herbal_preperation_image":"","preparation":"","plant_part_used":"","dosage":"","constituents":"","recipe_image":"","safety_post":"","safety":"","interactions":"","contraindications":"","sustainability_image_one":"","sustainability_image_two":"","faqs":null,"not_suitable_for":[]},"featured_image_urls_v2":{"full":["https:\/\/i.herbalreality.com\/wp-content\/uploads\/2024\/01\/14174746\/Horse-chestnut-Aesculus-hippocastanum.jpg",1000,667,false],"thumbnail":["https:\/\/i.herbalreality.com\/wp-content\/uploads\/2024\/01\/14174746\/Horse-chestnut-Aesculus-hippocastanum-600x600.jpg",600,600,true],"medium":["https:\/\/i.herbalreality.com\/wp-content\/uploads\/2024\/01\/14174746\/Horse-chestnut-Aesculus-hippocastanum-600x400.jpg",600,400,true],"large":["https:\/\/i.herbalreality.com\/wp-content\/uploads\/2024\/01\/14174746\/Horse-chestnut-Aesculus-hippocastanum.jpg",580,387,false],"banner_image":["https:\/\/i.herbalreality.com\/wp-content\/uploads\/2024\/01\/14174746\/Horse-chestnut-Aesculus-hippocastanum.jpg",1000,667,false],"gform-image-choice-sm":["https:\/\/i.herbalreality.com\/wp-content\/uploads\/2024\/01\/14174746\/Horse-chestnut-Aesculus-hippocastanum.jpg",300,200,false],"gform-image-choice-md":["https:\/\/i.herbalreality.com\/wp-content\/uploads\/2024\/01\/14174746\/Horse-chestnut-Aesculus-hippocastanum.jpg",400,267,false],"gform-image-choice-lg":["https:\/\/i.herbalreality.com\/wp-content\/uploads\/2024\/01\/14174746\/Horse-chestnut-Aesculus-hippocastanum.jpg",600,400,false]},"post_excerpt_stackable_v2":"","category_list_v2":"","author_info_v2":{"name":"","url":""},"comments_num_v2":"0 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