{"id":112401,"date":"2025-06-24T08:35:10","date_gmt":"2025-06-24T07:35:10","guid":{"rendered":"https:\/\/www.herbalreality.com\/?post_type=herb&#038;p=112401"},"modified":"2025-07-03T08:27:47","modified_gmt":"2025-07-03T07:27:47","slug":"black-horehound","status":"publish","type":"herb","link":"https:\/\/www.herbalreality.com\/herb\/black-horehound\/","title":{"rendered":"Black horehound"},"content":{"rendered":"","protected":false},"featured_media":112416,"parent":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"footnotes":"","beyondwords_generate_audio":"1","beyondwords_project_id":"47224","beyondwords_content_id":"9aa3fb0e-0125-44f6-b82e-0c3f317b1670","beyondwords_preview_token":"2c42efc0-f98f-4dca-84d7-d1054190b99a","beyondwords_player_content":"","beyondwords_player_style":"","beyondwords_language_code":"","beyondwords_language_id":"","beyondwords_title_voice_id":"","beyondwords_body_voice_id":"","beyondwords_summary_voice_id":"","beyondwords_error_message":"","beyondwords_disabled":"","beyondwords_delete_content":"","beyondwords_podcast_id":"","beyondwords_hash":"","publish_post_to_speechkit":"","speechkit_hash":"","speechkit_generate_audio":"","speechkit_project_id":"","speechkit_podcast_id":"","speechkit_error_message":"","speechkit_disabled":"","speechkit_access_key":"","speechkit_error":"","speechkit_info":"","speechkit_response":"","speechkit_retries":"","speechkit_status":"","speechkit_updated_at":"","_speechkit_link":"","_speechkit_text":""},"tags":[],"conditions":[685,696,698,695,700],"sustainability":[1576],"sense":[17,31,18,30,1821],"western_action":[991,1810,1822,993,994,997,1000,1001,1009,1010,1017,1018],"chinese_action":[],"ayurvedic_action":[],"energetics_action":[1498,1383,1497,1490,1496],"region":[1893],"class_list":["post-112401","herb","type-herb","status-publish","has-post-thumbnail","hentry","conditions-digestive-system","conditions-nervous-system","conditions-reproductive-system","conditions-respiratory-system","conditions-skin","sustainability-green-sustainability-status","sense-aromatic","sense-astringent-taste","sense-bitter","sense-sharp","sense-sour","western_action-anthelmintic","western_action-antidepressant","western_action-antiemetic","western_action-antimicrobial","western_action-antioxidant","western_action-antispasmodic","western_action-astringent","western_action-bitter","western_action-emmenagogue","western_action-expectorant","western_action-nervine","western_action-relaxant","energetics_action-bitter","energetics_action-cold","energetics_action-pungent","energetics_action-relaxing","energetics_action-sour","region-western-herbs"],"acf":{"last_reviewed":"20250618","herb_author":1910,"banner_text":"Black horehound is a traditional medicine for nausea","latin_name":"<i>Ballota nigra<\/i>","pseudonym_name":"","family_name":"","herb_summary":"Black horehound is traditionally used for nausea, indigestion, respiratory conditions, and relaxation. It is specific for nausea stemming from the nervous system such as motion sickness.","key_benefits":"Antiemetic\r\nNausea\r\nMotion sickness\r\nNervous indigestion\r\nRelaxant\r\nAntispasmodic\r\nExpectorant","how_does_it_feel":"<span style=\"font-weight: 400;\">The fresh plant has a foetid, musty smell, which has been described as \"disagreeably pungent\" and \"distinguished by its disagreeable odour\" (1,2).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The dried herb makes a beautifully golden-brown, dark yellow infusion which smells sour, grassy, slightly sweet, and reminiscent of damp hay.<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The taste is bitter, sour, and slightly sweet, developing into a more acrid sensation in the mouth, particularly at the back of the tongue. It is not unpleasant to drink, but does leave a sour aftertaste and an acrid sensation in the back of the throat.\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">A tingling in the mouth and throat quickly moves down to the stomach, and digestion is rapidly stimulated. This brings a wave of relaxation sweeping down through the body, and a light heaviness which is comforting as opposed to sedating. After a few minutes you may feel a slight tightening in the head, or the suggestion of a headache, but this lifts quickly leaving a clearer head. The expectorant action can be felt 10\u201315 minutes after drinking, with a clearing of the lungs facilitated by\u00a0 coughing up phlegm.\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The bitterness of the infusion can easily be balanced with other herbs to create a very pleasant tea, with <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/ginger\/\"><span style=\"font-weight: 400;\">ginger<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Zingiber officinale<\/span><\/i><span style=\"font-weight: 400;\">), <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/mint\/\"><span style=\"font-weight: 400;\">peppermint<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Mentha piperita<\/span><\/i><span style=\"font-weight: 400;\">) and <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/lemon-verbena\/\"><span style=\"font-weight: 400;\">lemon verbena<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Aloysia citrodora<\/span><\/i><span style=\"font-weight: 400;\">)working well as a combination (<\/span><i><span style=\"font-weight: 400;\">See <a href=\"https:\/\/www.herbalreality.com\/herb\/black-horehound#recipe\">recipe<\/a><\/span><\/i><span style=\"font-weight: 400;\">). <\/span>","hdif_image_1":112416,"hdif_image_2":112419,"hdif_image_3":112418,"hdif_video":"","sense":[17,31,18,30,1821],"what_can_i_use_it_for":"[caption id=\"attachment_112416\" align=\"alignright\" width=\"515\"]<img class=\" wp-image-112416\" src=\"https:\/\/i.herbalreality.com\/wp-content\/uploads\/2025\/06\/24082943\/Black-horehound-Ballota-nigra-1000x663.jpg\" alt=\"Black horehound (Ballota nigra)\" width=\"515\" height=\"341\" \/> Black horehound (<em>Ballota nigra<\/em>)[\/caption]\r\n\r\n<span style=\"font-weight: 400;\">Black horehound grows abundantly in the wild throughout the UK, mostly in England and Wales, less so in Scotland, and is easily identifiable for home remedy making (3). It is best to gather as it begins to flower in July, when the active constituents are at their highest (4,5).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Black horehound is an antiemetic, used to alleviate symptoms of nausea and vomiting, particularly when the cause is from the nervous system, such as travel sickness or an ear infection. Black horehound is also a helpful herb to use in cases of migraine, particularly if there is associated nausea. For any digestive upset such as indigestion or fullness after a meal, black horehound can be helpful as the bitter constituents stimulate the digestive processes. Due to the bitterness of the tea it can be more palatable if mixed with other herbs such as ginger, mint or <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/fennel\/\"><span style=\"font-weight: 400;\">fennel<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Foeniculum vulgare<\/span><\/i><span style=\"font-weight: 400;\">).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Black horehound has a calming effect on the nervous system, without being overly sedating. It can be used for mild anxiety, to relax muscle tension, or to help relaxation before bed. As a calming tea, the bitterness can be offset and complemented by herbs such as <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/chamomile\/\"><span style=\"font-weight: 400;\">chamomile<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Matricaria chamomila<\/span><\/i><span style=\"font-weight: 400;\">), <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/passionflower\/\"><span style=\"font-weight: 400;\">passionflower<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Passiflora incarnata<\/span><\/i><span style=\"font-weight: 400;\">), <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/limeflower\/\"><span style=\"font-weight: 400;\">limeflower<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Tilia spp<\/span><\/i><span style=\"font-weight: 400;\">) and <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/lemon-balm\/\"><span style=\"font-weight: 400;\">lemon balm<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Melissa officinalis<\/span><\/i><span style=\"font-weight: 400;\">).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Black horehound has an expectorant action and works well for clearing congestion in the lungs or to ease a cough. It can also be supportive for menstrual issues such as an irregular cycle or menstrual cramps. It can be used externally as a wash, poultice or compress for skin infections, rashes or wounds.\u00a0<\/span>","into_the_heart_of":"[caption id=\"attachment_112421\" align=\"alignright\" width=\"513\"]<img class=\" wp-image-112421\" src=\"https:\/\/i.herbalreality.com\/wp-content\/uploads\/2025\/06\/24083032\/Black-horehound-leaves-Ballota-nigra-1000x666.jpg\" alt=\"Black horehound (Ballota nigra)\" width=\"513\" height=\"342\" \/> Black horehound (<em>Ballota nigra<\/em>)[\/caption]\r\n\r\n<span style=\"font-weight: 400;\">Black horehound contains diterpenes, which have a strong bitter action, increasing bile flow, stimulating digestion, and having a protective action on the liver (3).\u00a0\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The relaxing and sedative action on the nervous system is due to the phenylpropanoids (arenarioside, forsythoside B, verbascoside, caffeoyl-malic acid) (6). <\/span><i><span style=\"font-weight: 400;\">In vitro,<\/span><\/i><span style=\"font-weight: 400;\"> these phenylpropanoids have been isolated from the aerial parts of black horehound and shown to bind to benzodiazepine, dopaminergic and morphine receptors (6). This provides some pharmacological explanation for the neuro-sedative actions of black horehound.\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The antioxidant<\/span> <span style=\"font-weight: 400;\">activity of the black horehound extracts has been demonstrated <\/span><i><span style=\"font-weight: 400;\">in vitro<\/span><\/i><span style=\"font-weight: 400;\">, with the antioxidant potential correlated to the total phenolic content and flavonoid content (5). The extracts of plants collected when flowering showed higher amounts of phenolics and flavonoids and were found to have the greatest antioxidant properties (5). The phenylpropanoids isolated from the aerial parts of black horehound have also demonstrated antioxidant activity, evidenced as an ability to scavenge reactive oxygen species <\/span><i><span style=\"font-weight: 400;\">in vitro<\/span><\/i><span style=\"font-weight: 400;\"> (6).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Isolated constituents from black horehound (arenarioside, forsythoside B and verbascoside) have been shown to have antibacterial activity, <\/span><i><span style=\"font-weight: 400;\">in vitro<\/span><\/i><span style=\"font-weight: 400;\"> (7). Specifically, the phenylpropanoids inhibited the growth of the gram-negative bacteria <\/span><i><span style=\"font-weight: 400;\">Proteus mirabilis<\/span><\/i><span style=\"font-weight: 400;\"> and the gram-positive <\/span><i><span style=\"font-weight: 400;\">Staphylococcus aureus<\/span><\/i><span style=\"font-weight: 400;\">, including methicillin-resistant strains (MRSA) (7). This action has been replicated in more recent research with extracts of black horehound exhibiting anti-pathogenic activity to MRSA <\/span><i><span style=\"font-weight: 400;\">in vitro<\/span><\/i><span style=\"font-weight: 400;\"> (8,9). This antibacterial activity could be due to a disruption in the way bacteria communicate (via quorum sensing), preventing virulence, biofilm formation and antibiotic resistance (10, 11). Although human clinical trials are lacking, this suggests potential for black horehound extracts to provide adjunct support alongside antibiotic treatment, particularly in resistant strains of infection.\u00a0\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Emotionally, black horehound can be used to calm elevated states of hysteria, and support the low energy seen in depressive states (12). It is indicated when there is nervous debility, panic attacks, low-spirits and convulsions or fainting (12).<\/span>","tradtional_uses":"[caption id=\"attachment_112422\" align=\"alignright\" width=\"506\"]<img class=\" wp-image-112422\" src=\"https:\/\/i.herbalreality.com\/wp-content\/uploads\/2025\/06\/24083040\/Black-horehound-plant-Ballota-nigra-1000x662.jpg\" alt=\"Black horehound (Ballota nigra)\" width=\"506\" height=\"335\" \/> Black horehound (<em>Ballota nigra<\/em>)[\/caption]\r\n\r\n<span style=\"font-weight: 400;\">Since the 13th century, black horehound as been used as a herbal medicine across Europe and North Africa for the treatment of animal bites, wounds, ulcers, haemorrhoids, menstruation disorders, toothaches, sores, nervousness, stomach upset and flatulence (10). It was considered to be a sedative, diuretic, digestive, anti-inflammatory, antiseptic, antiparasitic and haemostatic herb (10).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">In 1918, the British herbalist Richard Hool described the medicinal properties of black horehound as \u201cdiuretic, diaphoretic, emmenagogue, febrifuge, expectorant, pectoral, alterative, tonic, nervine, and antacid\u201d (13). It was used for amenorrhoea, menorrhagia, <\/span><a href=\"https:\/\/www.herbalreality.com\/condition\/dysmenorrhoea\/\"><span style=\"font-weight: 400;\">dysmenorrhoea<\/span><\/a><span style=\"font-weight: 400;\">, hysteria, gravel, dropsy, stomach afflictions, <\/span><a href=\"https:\/\/www.herbalreality.com\/condition\/cough\/\"><span style=\"font-weight: 400;\">coughs<\/span><\/a><span style=\"font-weight: 400;\">, hoarseness, <\/span><a href=\"https:\/\/www.herbalreality.com\/condition\/bronchitis\/\"><span style=\"font-weight: 400;\">bronchitis<\/span><\/a><span style=\"font-weight: 400;\">, consumption, loss of appetite, debility, general weakness, loss of energy, and nervous afflictions (13).\u00a0<\/span>\r\n<h3>Digestive<\/h3>\r\n<span style=\"font-weight: 400;\">Black horehound was considered to be one of the most efficacious and specific remedies available for biliousness (nausea, sickness, unsettled stomach), bilious colic, and sour belching. Hool describes \"the relief it affords is both prompt and certain, for if only a leaf or a piece of the stem be chewed, and the juice swallowed, it will be found to act as if a current of electricity had passed into the stomach, allaying all the symptoms momentarily\" (13). The bitter constituents increase bile flow, support digestion and protect the liver, and it was traditionally used in cases of malaria to treat a swollen liver and spleen (3).<\/span>\r\n<h3>Respiratory<\/h3>\r\n<span style=\"font-weight: 400;\">Black horehound was \u201cexceedingly useful\u201d for chronic coughs, bronchitis, tuberculosis and asthma by reducing the thickness of mucus and clearing the membranes to allow healing (13). As it not only corrects the mucus discharges, but soothes the irritation of the nerves caused by a fit of coughing. It was indicated for patients with nervous affections and was particularly useful in spasmodic tuberculosis and asthma (13).\u00a0<\/span>\r\n<h3>Reproductive<\/h3>\r\n<span style=\"font-weight: 400;\">It was described as \"simply wonderful\" for either suppressed or excessive menstruation: \"Black Horehound exerts such an influence as will restore the necessary equilibrium, it will be seen that it may be intelligently applicable to either case\" (13). It was also used for labour pains and described as an excellent remedy when combined with <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/motherwort\/\"><span style=\"font-weight: 400;\">motherwort<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Leonurus cardiaca<\/span><\/i><span style=\"font-weight: 400;\">) (13).<\/span>\r\n<h3>Topical<\/h3>\r\n<span style=\"font-weight: 400;\">Black horehound has a long history of topical use, with Dioscorides (40AD) suggesting the leaves be beaten with salt and applied to cure a dog bite, or mixed with honey to cleanse foul ulcers (14,15). Another use was to dry the stems to make wicks for butter lamps, and burn the leaves to repel biting insects (3).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Regarding modes of administration, it was used as an infusion, decoction, fluid extract, solid extract, powder, pills, tincture, fresh juice; or chewed in the mouth either in the fresh or dried state (13).<\/span>","what_practioners_say":"<h3><img class=\" wp-image-6364 alignright\" src=\"https:\/\/i.herbalreality.com\/wp-content\/uploads\/2022\/02\/21124321\/Subcategory-Conditions-digestive-system-600x600.jpg\" alt=\"Digestive system\" width=\"353\" height=\"353\" \/>Digestive system<\/h3>\r\n<span style=\"font-weight: 400;\">Black horehound is an excellent remedy for calming nausea and vomiting, particularly when the cause stems from the nervous system, as opposed to the stomach (4). This might include motion sickness, where the nausea is triggered by the inner ear and central nervous system (3,4). It is also valuable for nausea from emotional causes rooted in the nervous system such as anxiety, and can stimulate appetite in these cases. <\/span>\r\n\r\n<span style=\"font-weight: 400;\">Due to <\/span><span style=\"font-weight: 400;\">the bitter constituents and digestive stimulation, it is particularly helpful for nervous loss of appetite (anorexia), nervous indigestion and dyspepsia. In such cases it combines well with other gentle digestive nervines such as chamomile, lemon verbena, and lemon balm. Nausea often accompanies a migraine, and in these cases black horehound is a useful addition to a combination remedy which addresses the other individual symptoms and causes of the migraine.\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">During and following a bout of gastritis, there can be considerable nausea, and gastrointestinal symptoms to which black horehound can be supportive. Black horehound has a strong antispasmodic action on the upper digestive tract, making it particularly applicable to digestive issues in the stomach, as opposed to the lower intestines (16). For nausea, a queasy stomach, biliousness, bilious colic, a sour stomach and belching it combines well with <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/ginger\/\"><span style=\"font-weight: 400;\">ginger<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Zingiber officinale<\/span><\/i><span style=\"font-weight: 400;\">), <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/mint\/\"><span style=\"font-weight: 400;\">peppermint<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Mentha piperita<\/span><\/i><span style=\"font-weight: 400;\">), <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/catnip\/\"><span style=\"font-weight: 400;\">catnip<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Nepeta cataria<\/span><\/i><span style=\"font-weight: 400;\">), and <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/marshmallow\/\"><span style=\"font-weight: 400;\">marshmallow root<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Althea officinalis<\/span><\/i><span style=\"font-weight: 400;\">).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Black horehound is indicated for nausea and vomiting during pregnancy, and recommended by many renowned herbalists and reputable resources (3,4,12,16,17,18). However, caution is warranted during pregnancy due to a possible effect on the uterus and foetal development (19,20).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The tea is very bitter to drink and can be hard to tolerate, especially in cases of nausea, and combining with other herbs is often required. The tincture can be more palatable in cases of nausea, and can be diluted in water to be sipped, with some ginger or honey added (16).<\/span>\r\n<h3>Nervous system<\/h3>\r\n<span style=\"font-weight: 400;\">Black horehound is calming for the nervous system, and clinical trials have identified that when combined with <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/hawthorn\/\"><span style=\"font-weight: 400;\">hawthorn<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Crataegus monogyna<\/span><\/i><span style=\"font-weight: 400;\">), <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/passionflower\/\"><span style=\"font-weight: 400;\">passionflower<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Passiflora incarnata<\/span><\/i><span style=\"font-weight: 400;\">) and <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/valerian\/\"><span style=\"font-weight: 400;\">valerian<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Valeriana officinalis<\/span><\/i><span style=\"font-weight: 400;\">), black horehound reduces anxiety without compromising cognitive function (21,22,23). These studies provide evidence that hawthorn, passionflower, valerian, and black horehound are a helpful combination of herbs to consider for anxiety symptoms.\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Due to the combined effect on the digestive system and the relaxant nervine action, black horehound is an effective remedy when gastrointestinal symptoms are from a nervous system origin. This can include migraines with nausea, vestibular disturbances such as middle ear infections and labyrinthitis, travel sickness and nausea due to anxiety or panic.\u00a0\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Black horehound calms nervous system over-activity which can often be at the root of muscle tension, pain and spasm (3). Black horehound can be combined with herbs like <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/cramp-bark\/\"><span style=\"font-weight: 400;\">cramp bark<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Viburnum opulus<\/span><\/i><span style=\"font-weight: 400;\">), <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/skullcap\/\"><span style=\"font-weight: 400;\">skullcap<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Scutellaria lateriflora<\/span><\/i><span style=\"font-weight: 400;\">), <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/valerian\/\"><span style=\"font-weight: 400;\">valerian<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/jamaican-dogwood\/\"><span style=\"font-weight: 400;\">Jamaican dogwood<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Piscidia piscipula<\/span><\/i><span style=\"font-weight: 400;\">) to ease muscle tension and chronic pain which stems from nervous system activation.\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Black horehound can be used for mild sleep disorders (24). <\/span><a href=\"https:\/\/www.herbalreality.com\/condition\/insomnia\/\"><span style=\"font-weight: 400;\">Insomnia<\/span><\/a><span style=\"font-weight: 400;\"> can often be the result of nervous system activation, and in these cases black horehound can be added to a herbal formula to meet the patient\u2019s individual needs. There is some evidence from animal studies that black horehound may have a mild antidepressant action (10). Therefore, the anxiolytic, antidepressant and mild sedative action suggests black horehound could be a suitable herb for certain cases of insomnia, particularly when combined with other herbs to support the root cause and other associated symptoms.\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Black horehound is also indicated when someone presents with panic attacks, fainting due to increased sympathetic nervous activation, hysteria and hypochondria (12,24).<\/span>\r\n<h3><img class=\" wp-image-6371 alignleft\" src=\"https:\/\/i.herbalreality.com\/wp-content\/uploads\/2022\/02\/21124316\/Subcategory-Conditions-reproductive-system-600x600.jpg\" alt=\"Reproductive system\" width=\"360\" height=\"360\" \/>Reproductive system<\/h3>\r\n<span style=\"font-weight: 400;\">Black horehound can be used to help normalise menstrual function by suppressing a heavy or excessive menstrual bleed (menorrhagia), bringing on an absent period, and regulating oligomenorrhea or amenorrhea (3,4). The antispasmodic actions also indicate black horehound as a herb to include in a herbal mix for menstrual cramps (3).<\/span>\r\n<h3>Respiratory system<\/h3>\r\n<span style=\"font-weight: 400;\">The expectorant action of black horehound will clear mucus from the lungs, making it useful for a chronic chesty cough or bronchitis (3,12). The antispasmodic action also suits black horehound to dry, tickly, spasmodic coughs and asthma (3,12). It combines well with <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/hyssop\/\"><span style=\"font-weight: 400;\">hyssop<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Hyssopus officinalis<\/span><\/i><span style=\"font-weight: 400;\">), lobelia (<\/span><i><span style=\"font-weight: 400;\">Lobelia inflata<\/span><\/i><span style=\"font-weight: 400;\">) (a practitioner-only herb), <\/span><a href=\"https:\/\/www.herbalreality.com\/herb\/mullein\/\"><span style=\"font-weight: 400;\">mullein<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><i><span style=\"font-weight: 400;\">Verbascum thapsus<\/span><\/i><span style=\"font-weight: 400;\">) and marshmallow to support the lungs.\u00a0<\/span>\r\n<h3>Integumentary system<\/h3>\r\n<span style=\"font-weight: 400;\">Black horehound has traditionally been used as a wash or poultice for wounds and infections, ulcers, skin rashes and boils (3,8,12). This use is supported by research demonstrating antibacterial activity, including against methicillin-resistant strains of <\/span><i><span style=\"font-weight: 400;\">Staphylococcus aureus<\/span><\/i><span style=\"font-weight: 400;\"> (MRSA) (7,8,9). The antibacterial activity demonstrated by <\/span><i><span style=\"font-weight: 400;\">in vitro<\/span><\/i><span style=\"font-weight: 400;\"> research suggests that in cases of MSRA, black horehound would be a useful herb both externally and as an internal herbal medicine (8, 9). Although there is no clinical evidence from human clinical trials, black horehound may be a herb to consider internally and externally alongside antibiotic treatment, especially against resistant strains of infection (8,9).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Rectally, black horehound can be used as an enema or suppository for intestinal worm infestations (24,25).<\/span>","research":"[caption id=\"attachment_112415\" align=\"alignright\" width=\"498\"]<img class=\" wp-image-112415\" src=\"https:\/\/i.herbalreality.com\/wp-content\/uploads\/2025\/06\/24082933\/Black-horehound-tincture-Ballota-nigra-1000x666.jpg\" alt=\"Black horehound tincture (Ballota nigra)\" width=\"498\" height=\"332\" \/> Black horehound tincture (<em>Ballota nigra<\/em>)[\/caption]\r\n\r\n<span style=\"font-weight: 400;\">There is limited clinical evidence to support the use of black horehound, and the indications for use are based on traditional use, <\/span><i><span style=\"font-weight: 400;\">in vitro<\/span><\/i><span style=\"font-weight: 400;\"> research to determine the plant constituents, and the known actions of these constituents. Only a small number of studies have investigated pharmacological properties of isolated constituents. More detail can be found regarding isolated constituents above (<\/span><i><span style=\"font-weight: 400;\">Into the heart of black horehound<\/span><\/i><span style=\"font-weight: 400;\">).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">There are no clinical trials investigating black horehound as a single ingredient, although there are three clinical trials investigating it as part of a mixed ingredient herbal supplement (Euphytose\u00ae) containing Crataegus monogyna (hawthorn), Ballota nigra (black horehound), Passiflora incarnata (passionflower) and Valeriana officinalis (valerian). All three studies showed an improvement in anxiety symptoms without sedation or a reduction in cognitive function. However, it is not possible to separate the effects of the other herbs in the formula from the black horehound, limiting the evidence these studies provide for this monograph. The most recent and well controlled study is outlined below for context.<\/span>\r\n<h3>The chronic effects of a combination of herbal extracts (Euphytose\u00ae) on psychological mood state and response to a laboratory stressor: A randomised, placebo-controlled, double blind study in healthy humans<\/h3>\r\n<span style=\"font-weight: 400;\">The mixed ingredient herbal supplement, Euphytose\u00ae (50 mg <\/span><i><span style=\"font-weight: 400;\">Valeriana officinalis<\/span><\/i><span style=\"font-weight: 400;\">, 40 mg <\/span><i><span style=\"font-weight: 400;\">Passiflora incarnate<\/span><\/i><span style=\"font-weight: 400;\">, 10 mg <\/span><i><span style=\"font-weight: 400;\">Crataegus sp<\/span><\/i><span style=\"font-weight: 400;\">., 10 mg <\/span><i><span style=\"font-weight: 400;\">Ballota nigra<\/span><\/i><span style=\"font-weight: 400;\">) or placebo was administered to 31 healthy participants. In this crossover study the participants took the supplement (two tablets, three times per day) for 14\u2009days, with a 28-day washout between conditions.\u00a0 Anxiety (State-Trait Anxiety Inventory), mood and physiological measures of stress (heart rate, galvanic skin response, salivary \u03b1-amylase and cortisol levels) and cognitive performance were measured before and after a multitasking stressor. <\/span>\r\n\r\n<span style=\"font-weight: 400;\">After the herbal supplementation period there was a significant reduction in subjective anxiety, and stress (lower salivary \u03b1-amylase and galvanic skin response) in response to the multitasking stressor, compared to the placebo. There was no difference in cognitive performance across each treatment or between the two conditions. This suggests that despite the reported sedating effects of some of the extracts contained within the treatment, the herbal supplement decreased stress and anxiety without any changes to negative effects on cognitive performance (23).<\/span>\r\n<h3>Neuro-sedative and antioxidant activities of phenylpropanoids from ballota nigra<\/h3>\r\n<span style=\"font-weight: 400;\">In this <\/span><i><span style=\"font-weight: 400;\">in vitro<\/span><\/i><span style=\"font-weight: 400;\"> study, five phenylpropanoids (arenarioside, forsythoside B, verbascoside, caffeoyl-malic acid) were isolated from an alcohol extract of the aerial parts of black horehound (6). The isolated compounds are able to bind to the benzodiazepine, dopaminergic, and morphine receptors in rodent muscle and brain tissues. This data provides some pharmacological explanation for the neuro-sedative actions of black horehound (6). <\/span>\r\n\r\n<span style=\"font-weight: 400;\">The study also demonstrated antioxidant activities of these phenylpropanoids, against reactive oxygen species liberated from inflammatory white blood cells. The antioxidant activity, evidenced by an ability to scavenge reactive oxygen species, was comparable to the antioxidant supplement N-acetyl cysteine (NAC) (6).\u00a0<\/span>\r\n<h3>Antibiotic treatment <span style=\"font-weight: 400;\">\u00a0<\/span><\/h3>\r\n<span style=\"font-weight: 400;\">Two studies are presented here to outline the potential for black horehound to be used as an adjunct therapy alongside antibiotic treatment. It should be noted that these are <\/span><i><span style=\"font-weight: 400;\">in vitro<\/span><\/i><span style=\"font-weight: 400;\"> studies, using cell cultures, and are not clinical trials, but they do outline a potential indication for use from the research.<\/span>\r\n<h3>Effects of extracts from Italian medicinal plants on planktonic growth, biofilm formation and adherence of methicillin-resistant\u00a0Staphylococcus aureus<span style=\"font-weight: 400;\">\u00a0<\/span><\/h3>\r\n<span style=\"font-weight: 400;\">Using cultured methicillin-resistant\u00a0<\/span><i><span style=\"font-weight: 400;\">Staphylococcus aureus, <\/span><\/i><span style=\"font-weight: 400;\">the study reported the water extract (but not alcohol extract) of black horehound inhibited biofilm formation. The water extract was a crude extract of the whole herb, using 1 g herb per 50 ml water, which has practical significance for the replication of this extract at safe dosages. <\/span>\r\n\r\n<span style=\"font-weight: 400;\">The black horehound water extract was one of only five of the 168 plant extracts which inhibited the biofilm formation. The authors concluded that the results validate the efficacy if black horehound as a topical application for skin and soft tissue infections (8).\u00a0\u00a0<\/span>\r\n<h3>Quorum sensing inhibitors of <i>Staphylococcus aureus<\/i> from Italian medicinal plants<\/h3>\r\n<span style=\"font-weight: 400;\">The study measured the production of <\/span><i><span style=\"font-weight: 400;\">\u03b4<\/span><\/i><span style=\"font-weight: 400;\">-hemolysin (a toxin produced by S<\/span><i><span style=\"font-weight: 400;\">taphylococcus aureus<\/span><\/i><span style=\"font-weight: 400;\"> which plays a role in bacterial virulence) in cultured <\/span><i><span style=\"font-weight: 400;\">Staphylococcus aureus.<\/span><\/i>\r\n\r\n<span style=\"font-weight: 400;\">Black horehound was one of only three of the 104 plants tested which lowered the production of <\/span><i><span style=\"font-weight: 400;\">\u03b4<\/span><\/i><span style=\"font-weight: 400;\">-hemolysin. This demonstrated the alcohol extract to have anti-quorum sensing activity (ability to disrupt bacterial communication systems known as quorum sensing), suggesting a mechanism for preventing biofilm formation, reducing virulence factor production, and inhibiting antibiotic resistance (9).\u00a0\u00a0<\/span>","did_you_know":"<span style=\"font-weight: 400;\">The Latin name <\/span><i><span style=\"font-weight: 400;\">Ballota<\/span><\/i><span style=\"font-weight: 400;\"> comes from the Greek <\/span><i><span style=\"font-weight: 400;\">ballo<\/span><\/i><span style=\"font-weight: 400;\"> which means 'to reject', as the strong offensive odour means cattle and other farm animals reject it, leaving it remaining in the fields they are grazing (2,14). The smell of the fresh plant also accounts for several of the common names including stinking horehound (2).<\/span>","additional_information_right":{"illustration":112417},"additional_information_left":{"botany":"Black horehound is a winter-green, semi-evergreen perennial with a strongly aromatic and foetid scent (27,28,29). The erect but scraggy plant grows to 0.5\u20131 m, with a spread of 0.5\u20131m (1,29).\r\n\r\nLeaves are opposite along a square stem, simple, pointed ovate, coarsely-toothed and rough-textured, mid to pale green, and green all year around (1,14,29). The leaves are similar to a stinging nettle, but easily distinguishable by the flowers, scent, and the lack of stinging hairs (14).\r\n\r\nThe pink\/purple flowers are in whorls of small, two-lipped flowers in the axils of upper leaves, in funnel-shaped calyx with long teeth (1,18,29). The upper lip of the flower is erect and slightly concave, and the lower lip divided into three lobes with the outer lobes smaller than the central one (2). Black horehound flowers in summer and autumn, from June to October (28).","common_names":"<ul>\r\n \t<li>Stinking horehound<\/li>\r\n \t<li>Black stinking horehound<\/li>\r\n \t<li>Stinking horehound<\/li>\r\n \t<li>Dunny nettle<\/li>\r\n \t<li>Stinking roger<\/li>\r\n \t<li>Hairy hound black angelica<\/li>\r\n \t<li>False horehound<\/li>\r\n \t<li>Fetid horehound<\/li>\r\n \t<li>Hairhound<\/li>\r\n \t<li>Henbit<\/li>\r\n<\/ul>","safety":"As with all herbs in the mint family, black horehound is considered safe to consume as a herbal remedy (12). Black horehound has low toxicity, however, due to the lack of data on efficacy and safety from human trials, excessive use should be avoided (20).","interactions":"There are no side effects or drug interactions reported (4,20,24).\r\n\r\nSince some isolated constituents of black horehound bind to dopamine receptors in vitro, theoretically, black horehound might have additive effects when used with dopamine agonists such as bromocriptine (Parlodel), levodopa, pramipexole (Mirapex), and ropinirole (Requip) (6,24).","contraindications":"None documented (10,20)\r\n\r\nDue to the lack of phytochemical, pharmacological and toxicity data, and the potential for an impact on the uterus or foetal development, black horehound should be avoided during pregnancy and breastfeeding (19,20,24). Only consume during pregnancy and breast feeding when under the guidance of a qualified herbalist or medical practitioner (19,20).\r\n\r\nYou can find qualified medical herbal professionals on our page <a href=\"https:\/\/www.herbalreality.com\/resources\/find-herbalist\/\">Where to find a herbalist<\/a>.","preparation":"<ul>\r\n \t<li><strong>Infusion<\/strong><\/li>\r\n \t<li><strong>Tincture\/ Fluid extract<\/strong><\/li>\r\n \t<li><strong>Topical application:<\/strong> Wash, compress, poultice<\/li>\r\n<\/ul>","dosage":"<ul>\r\n \t<li><strong>Tincture (ratio 1:5| 25\u201345%):<\/strong> 1\u20133 ml, three times per day (4,20). 10\u201315 drops in water, three times per day (24). Up to 10\u201320 ml per week (17)<\/li>\r\n \t<li><strong>Fluid extract (1:1 | 25%):<\/strong> 1\u20133 ml, three times per day (18,20)<\/li>\r\n \t<li><strong>Infusion:<\/strong> 2\u20134 g dried herb (1\u20132 teaspoons), three times per day (4,18,20)<\/li>\r\n \t<li><strong>Poultice:<\/strong> Bruise leaves and apply to infected wounds or skin ulcers (3,12)<\/li>\r\n \t<li><strong>Wash:<\/strong> 1 g of herb per 50 ml water (8)<\/li>\r\n<\/ul>","constituents":"<ul>\r\n \t<li><strong>Terpenes:<\/strong> Iridoids; diterpenoids (Marrubiin, ballonigrin, ballotinone, Ballotenol, pre-leosibirin); triterpenoids (oleanolic acid, ursolic acid) (4,10,20)<\/li>\r\n \t<li><strong>Flavonoids:<\/strong> Luteolin, apigenin-7-glucoside, vicenin (4,20)<\/li>\r\n \t<li><strong>Volatile oils (0.02%):<\/strong> Foetida (95.8% of the total oils), \u03b2-caryophyllene, germacrene D, \u03b1 and \u03b2-pinene, linalool, sabinene (18,20,26)<\/li>\r\n \t<li><strong>Phenylpropanoids:<\/strong> Verbascoside, forsythoside-B, arenarioside, ballotetroside, alyssonoside, lavandulifoliside, angoroside, caffeoyl malic acid (6,20)<\/li>\r\n<\/ul>\r\n<span style=\"color: #ed6e17;\"><i>Please note: Extracts of plants collected when in flower have been shown to have higher amounts of phenolics and flavonoids than prior to, or after flowering (5).<\/i><\/span>","plant_part_used":"<ul>\r\n \t<li>Aerial parts<\/li>\r\n \t<li>Flowering tops<\/li>\r\n<\/ul>"},"habitat":"<span style=\"font-weight: 400;\">Black horehound is native to Europe and North Africa (Algeria, Morocco, Tunisia), and has been introduced and naturalised across the UK and North America (Alabama, Maryland, New York, Wisconsin); South America (Argentina) Kazakhstan, Kirgizstan, West Siberia, and New Zealand (27,30). It can be found in forests, woodlands, shrublands, hedgerows, road verges and waste ground, grasslands, shady meadows, along water courses on disturbed nutrient rich soils near habitations and urban areas (<\/span><span style=\"font-weight: 400;\">27<\/span><span style=\"font-weight: 400;\">).<\/span>","sustainability":"[caption id=\"attachment_97187\" align=\"alignright\" width=\"312\"]<a href=\"https:\/\/www.herbalreality.com\/herbalism\/sustainability-social-welfare\/herb-species-sustainability-guide\/\"><img class=\" wp-image-97187\" src=\"https:\/\/i.herbalreality.com\/wp-content\/uploads\/2025\/05\/25101030\/Green-sustainability-status-1000x1000.png\" alt=\"Green Sustainability Status\" width=\"312\" height=\"312\" \/><\/a> Not currently on risk lists but complete data may be missing on the status of the species. Read more in our <a href=\"https:\/\/www.herbalreality.com\/herbalism\/sustainability-social-welfare\/herb-species-sustainability-guide\/\">sustainability guide<\/a>.[\/caption]\r\n\r\n<span style=\"font-weight: 400;\">There is no CITES (Convention on International Trade in Endangered Species of Wild Fauna and Flora) Legislation on trade of this species (32).\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Black horehound does not have a status ranking and there is no information on the distribution although it appears in several states\u00a0 across North America (33). It does not appear on the U.S. Endangered Species act or the Committee on the Status of Endangered Wildlife in Canada (COSEWIC) (33).\u00a0\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The International Union for Conservation of Nature (IUCN) most recently conducted a European assessment of <\/span><i><span style=\"font-weight: 400;\">Ballota nigra<\/span><\/i><span style=\"font-weight: 400;\"> in 2012 and listed it as \u201cLeast Concern (LC) (27). They state that the species is widely distributed across Europe, with a large overall population (27). Despite local declines it is considered unlikely to be declining fast enough to qualify for listing in a more threatened category (27). The Vascular Plant, Red Data List, For Great Britain also listed black horehound horehound as least Concern (LC) as it is widespread and abundant (<\/span><span style=\"font-weight: 400;\">31<\/span><span style=\"font-weight: 400;\">). A plant is considered LC when it has been evaluated against the criteria and does not qualify for critically endangered, endangered, vulnerable or near threatened (<\/span><span style=\"font-weight: 400;\">31<\/span><span style=\"font-weight: 400;\">).<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Habitat loss and over-harvesting from the wild are two of the biggest threats faced by medicinal plant species. There are an increasing number of well-known herbal medicines at risk of extinction. We must, therefore, ensure that we source our medicines with sustainability in mind.<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The herb supplement industry is growing at a rapid rate and until recent years a vast majority of medicinal plant produce in global trade was of unknown origin. There are some very real and urgent issues surrounding sustainability in the herb industry. These include environmental factors that affect the medicinal viability of herbs, the safety of the habitats that they are taken from, as well as the welfare of workers in the trade.<\/span>\r\n\r\n<span style=\"font-weight: 400;\">The botanical supply chain efforts for improved visibility (transparency and traceability) into verifiably sustainable production sites around the world is now certificated through the emergence of credible international voluntary sustainability standards (VSS).<\/span><span style=\"font-weight: 400;\">\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Read our article on <\/span><a href=\"https:\/\/www.herbalreality.com\/herbalism\/safety\/herbal-quality-safety-what-know-before-you-buy\/\"><span style=\"font-weight: 400;\">Herbal quality &amp; safety: What to know before you buy<\/span><\/a><span style=\"font-weight: 400;\">\u00a0and <\/span><a href=\"https:\/\/www.herbalreality.com\/herbalism\/western-herbal-medicine\/where-your-herbs-come-from\/\"><span style=\"font-weight: 400;\">Sustainable sourcing of herbs<\/span><\/a><span style=\"font-weight: 400;\"> to learn more about what to look for and questions to ask suppliers about sustainability.<\/span>","sustainability_content":"","sustainability_alternatives":"","quality_control":"<span style=\"font-weight: 400;\">Herbal medicines are often very safe to take; however, their safety and efficacy can be jeopardised by quality issues. So, it is important to buy herbal medicines from a reputable supplier, from sources known to test their herbs to ensure there is no contamination, adulteration or substitution with incorrect plant matter, as well as ensuring that recognised marker compounds are at appropriate levels in the herbs.<\/span>\r\n\r\n<span style=\"font-weight: 400;\">Some important quality assurances to look for are certified organic labelling, the correct scientific\/botanical name, and the availability of information from the supplier about ingredient origins. A supplier should be able to tell you where the herbs have come from, what contaminants are not in the herb, and what the primary compounds are.<\/span>","how_to_grow":"<span style=\"font-weight: 400;\">Propagation is by root division in spring, growing well in well drained, nitrogen rich soil in full sun (3,29). Also grows from seed directly into the garden, and will continue to self-seed (14). It is both frost and drought resistant (18).<\/span>","recipe":"[caption id=\"attachment_112420\" align=\"alignright\" width=\"512\"]<img class=\" wp-image-112420\" src=\"https:\/\/i.herbalreality.com\/wp-content\/uploads\/2025\/06\/24083023\/Black-horehound-flowers-Ballota-nigra-1000x667.jpg\" alt=\"Black horehound (Ballota nigra)\" width=\"512\" height=\"341\" \/> Black horehound (<em>Ballota nigra<\/em>)[\/caption]\r\n<h3>Upset tummy tea<\/h3>\r\n<span style=\"font-weight: 400;\">This tea blend is for sipping if you feel nauseous due to travel sickness, a tummy bug, or an emotional cause such as anxiety. It will ease the nausea, settle the tummy, stimulate the digestion and ease acidic sensation in the stomach that can accompany nausea. It can also help if you feel a little nauseous after a meal or have overeaten.\u00a0<\/span>\r\n<h4>Ingredients<b>\u00a0<\/b><\/h4>\r\n<ul>\r\n \t<li><span style=\"font-weight: 400;\">Black horehound 15g<\/span><\/li>\r\n \t<li><span style=\"font-weight: 400;\">Peppermint 10 g<\/span><\/li>\r\n \t<li><span style=\"font-weight: 400;\">Lemon verbena 10 g<\/span><\/li>\r\n \t<li><span style=\"font-weight: 400;\">Marshmallow root 10 g<\/span><\/li>\r\n \t<li><span style=\"font-weight: 400;\">Dried ginger root 5 g<\/span><\/li>\r\n<\/ul>\r\n<h4>Method<\/h4>\r\n<span style=\"font-weight: 400;\">Mix together the dried herbs to store in an airtight container. Using 5 g (~1 teaspoon) per\u00a0 cup, add the herbs to a teapot, cover in boiling water and leave to steep for 10\u201315 minutes. Sip slowly, drinking between one and three cups per day.<\/span>","references":"<ol>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blamey M, Fitter R, Fitter AH.\u00a0<\/span><i><span style=\"font-weight: 400;\">Wild Flowers of Britain and Ireland: 2Nd Edition<\/span><\/i><span style=\"font-weight: 400;\">. A &amp; C Black; 2013.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Grieve M, Leyel CF, Marshall M. <\/span><i><span style=\"font-weight: 400;\">A Modern Herbal. the Medicinal, Culinary, Cosmetic and Economic Properties, Cultivation and Folk-Lore of Herbs, Grasses, Fungi, Shrubs &amp; Trees with All Their Modern Scientific Uses<\/span><\/i><span style=\"font-weight: 400;\">. Dover Publications; 1982.\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Burton-Seal J. and Seal M. <\/span><i><span style=\"font-weight: 400;\">Wayside Medicine: forgotten plants and how to use them<\/span><\/i><span style=\"font-weight: 400;\">. Merlin Unwin Books; 2017.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hoffmann D.\u00a0<\/span><i><span style=\"font-weight: 400;\">Medicinal Herbalism, The Science and Practice of Herbal Medicine<\/span><\/i><span style=\"font-weight: 400;\">. Healing Arts Press; 2003.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Makowczy\u0144ska, J., Grzegorczyk-KAROLAK, I., &amp; Wysoki\u0144ska, H. Antioxidant Activity of Tissue Culture-Raised <\/span><i><span style=\"font-weight: 400;\">Ballota Nigra<\/span><\/i><span style=\"font-weight: 400;\"> L. Plants Grown <\/span><i><span style=\"font-weight: 400;\">Ex Vitro<\/span><\/i><span style=\"font-weight: 400;\">. <\/span><i><span style=\"font-weight: 400;\">Acta poloniae pharmaceutica<\/span><\/i><span style=\"font-weight: 400;\">. 2015; 72(4); 769\u2013775.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Daels-Rakotoarison DA, Seidel V, Gressier B, Brunet C, Tillequin F, Bailleul F, Luyckx M, Dine T, Cazin M, Cazin JC. Neurosedative and antioxidant activities of phenylpropanoids from Ballota nigra. <\/span><i><span style=\"font-weight: 400;\">Arzneimittelforschung<\/span><\/i><span style=\"font-weight: 400;\">. 2000;50(01):16-23. <a href=\"https:\/\/doi.org\/10.1055\/s-0031-1300158\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1055\/s-0031-1300158\u00a0<\/a><\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Didry N, Seidel V, Dubreuil L, Tillequin F, Bailleul F. Isolation and antibacterial activity of phenylpropanoid derivatives from <\/span><i><span style=\"font-weight: 400;\">Ballota nigra<\/span><\/i><span style=\"font-weight: 400;\">. <\/span><i><span style=\"font-weight: 400;\">Journal of ethnopharmacology<\/span><\/i><span style=\"font-weight: 400;\">. 1999; 1;67(2):197-202. <\/span><a href=\"https:\/\/doi.org\/10.1016\/S0378-8741(99)00019-7\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1016\/S0378-8741(99)00019-7<\/span><\/a><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Quave CL, Plano LR, Pantuso T, Bennett BC. Effects of extracts from Italian medicinal plants on planktonic growth, biofilm formation and adherence of methicillin-resistant Staphylococcus aureus. <\/span><i><span style=\"font-weight: 400;\">Journal of ethnopharmacology<\/span><\/i><span style=\"font-weight: 400;\">. 2008;118(3):418-28. <\/span><a href=\"https:\/\/doi.org\/10.1016\/j.jep.2008.05.005\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1016\/j.jep.2008.05.005<\/span><\/a><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Quave CL, Plano LR, Bennett BC. Quorum sensing inhibitors of Staphylococcus aureus from Italian medicinal plants<\/span><i><span style=\"font-weight: 400;\">. 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400;\">https:\/\/unitedplantsavers.org\/ups-list-of-herbs-analogs\/<\/span><\/a><\/li>\r\n<\/ol>","related_condition":[3375,9321],"related_herb":[94,4728],"related_article":[5639,8911],"herb_overview_content_one":"","herb_overview_content_two":"","herb_overview_content_three":"","herb_overview_content_four":"","herb_overview_content_five":"","herb_overview_content_six":"","herb_overview_content_seven":"","herb_overview_content_eight":"","botany":"","botanical_description":"","botanical_image":null,"common_names":"","herbal_preperation_image":null,"preparation":"","plant_part_used":"","dosage":"","constituents":"","recipe_image":null,"safety_post":null,"safety":"","interactions":"","contraindications":"","sustainability_image_one":null,"sustainability_image_two":null,"faqs":null,"not_suitable_for":[]},"featured_image_urls_v2":{"full":["https:\/\/i.herbalreality.com\/wp-content\/uploads\/2025\/06\/24082943\/Black-horehound-Ballota-nigra.jpg",1417,940,false],"thumbnail":["https:\/\/i.herbalreality.com\/wp-content\/uploads\/2025\/06\/24082943\/Black-horehound-Ballota-nigra-600x600.jpg",600,600,true],"medium":["https:\/\/i.herbalreality.com\/wp-content\/uploads\/2025\/06\/24082943\/Black-horehound-Ballota-nigra-1000x663.jpg",1000,663,true],"large":["https:\/\/i.herbalreality.com\/wp-content\/uploads\/2025\/06\/24082943\/Black-horehound-Ballota-nigra-1300x862.jpg",580,385,true],"banner_image":["https:\/\/i.herbalreality.com\/wp-content\/uploads\/2025\/06\/24082943\/Black-horehound-Ballota-nigra-1417x800.jpg",1417,800,true],"gform-image-choice-sm":["https:\/\/i.herbalreality.com\/wp-content\/uploads\/2025\/06\/24082943\/Black-horehound-Ballota-nigra.jpg",300,199,false],"gform-image-choice-md":["https:\/\/i.herbalreality.com\/wp-content\/uploads\/2025\/06\/24082943\/Black-horehound-Ballota-nigra.jpg",400,265,false],"gform-image-choice-lg":["https:\/\/i.herbalreality.com\/wp-content\/uploads\/2025\/06\/24082943\/Black-horehound-Ballota-nigra.jpg",600,398,false]},"post_excerpt_stackable_v2":"","category_list_v2":"","author_info_v2":{"name":"","url":""},"comments_num_v2":"0 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